Association of High Sensitivity C-Reactive Protein in Polycystic Ovary Syndrome

Objective: This study is aimed to see the level of high sensitivity C-reactive protein (hs-CRP) and its association with manifestations polycystic ovary syndrome (PCOS). Design: cross-sectional was conducted over a period one year (January 2017 December 2018) in department Endocrinology University hospital. Participants: Fifty-five PCOS patients diagnosed on basis revised Rotterdam diagnostic criteria 2003 50 age-matched healthy controls [PCOS vs. Control- BMI (kg/m2): 25.47±4.65 20.68±3.51, p<0.001]. Main outcome measures: hs-CRP level, Methods: After relevant history physical examinations, blood taken fasting state during follicular phase menstrual cycle measure total testosterone (TT), luteinizing hormone (LH), follicle stimulating (FSH) hs-CRP. Hormones were measured by chemiluminescent microparticle immuno-assay nephelometric technique. Results: (mg/L) found significantly higher [1.67 (0.69, 2.54) 0.94 (0.30, 1.42), p=0.006] even after adjustment for age [OR (95% CI): 1.585 (1.093, 2.299), p=0.015]. Also status (>5 mg/L) them than that controls; but only non-obese (BMI <25 kg/m2) participants [7.27% 0.0%, p=0.018]. hs- CRP showed no significant correlation predictive any including age, BMI, waist circumference, TT LH/FSH ratio [p=NS all] Conclusions: Patients had without manifestations. J Dhaka Med Coll. 2021; 30(2) : 142-148